In this issue:
- Message from the Coordinating Center
- HCSRN Meeting Highlights
- PCORI Initiative Update
- Additional Funding Opportunities
- CRN Calendar
Message from the Coordinating Center
Pilot Projects Program Update
The CRN invited 27 investigators who submitted Letters of Intent to submit full applications for the CRN Pilot Projects Program. We expect to fund four or five applications.
We will be holding a Q&A style webinar on Monday, April 14, from 12 to 2 pm, PDT, covering information related to the Pilot Project Application Submissions. All investigators, co-investigators, grants administrator and others who may be involved in preparing an Application are invited to attend. We will send a reminder to all investigators invited to submit a Full Pilot Project Application with webinar URL information.
We are gearing up for the big conference next week. Check below for details on where we'll be. See you at HCSRN!
-Larry, Heather & Melissa
HCSRN Meeting Highlights
9am-5pm CRN Scholars Meeting
1-5pm VDW Implementation Group, part 1.
This is the regular working meeting among VDW implementers. Topics tend to be technical and detailed. Those wanting insight in to how the VDW operates at the micro level may wish to attend.
10-11:15am Poster Session Competition, CRN Scholar Entrants:
- Pamala A. Pawloski, PharmD: Validation of Colony Stimulating Factor (CSF) Data Within the HCSRN Virtual Data Warehouse.
- Jason P. Lott, MD, MSHP: Time to Surgery for Melanoma.
11:30-1pm Early Career Investigator Presentations, CRN Scholars
- Hazel B. Nichols, PhD, National Institute of Environmental Health Sciences: Discontinuation of Tamoxifen for Primary Prevention of Breast Cancer in the Sister Study Observational Cohort.
- Matthew P. Banegas, PhD, National Cancer Institute: Renal Cell Cancer: A Shift in Approaches for Advanced Disease Treatment in the United States.
1:15-3:00pm CRN Steering Committee, part 1
3:15-4:45pm Concurrent Session A1: Cancer Methods and Technology
- Mara Epstein: Statin Use and Risk of Multiple Myeloma.
10-11:15am Poster Session 2: Cancer
- Jessica Chubak: Cancer Research Network: Cancer Incidence, Prevalence, and Health Plan Enrollment.
- Mark Hornbrook: 1) Incremental Medical Care Costs of Prostate Cancer for Medicare Beneficiaries and 2) Strategies Used by Rectal Cancer Survivors to Improve Bowel Function Other than Diet, Exercise, or Dietary Supplements.
- Pam Pawloski: 1) Disparities in Oral Capecitabine Use: A Chart Review of Older Patients Treated in the Community and 2) Pharmacogenomic Testing in Patients with Chronic Pain to Support Personalized Medicine.
- Deb Ritzwoller: Cancer Recurrence Detection and Timing Using CRN and Medicare Claims Data.
- Dori Rosenberg: Using Health Risk Assessments to Understand Older Adult Sedentary Time.
2:30-6:30 Dissemination & Implementation Training
Kathy Mazor, Brian Mittman, Russ Glassgow, and Borsika Rabin.
2:30-4:30 VDW Implementation Group (VIG) Meeting, part 2.
Scientists representing research consortia will present on their use of the VDW. The goal is to improve the exchange of information, learnings, and priorities between VDW implementers and VDW users. Mini-Sentinel, Mental Health Research Network, Cancer Research Network, and PORTAL projects will all be presenting. Scientists at all levels and experiences are invited to attend.
Concurrent Session C1: Colorectal Cancer
- Grace Clarke Hillyer: Evaluation of Screening Colonoscopy per Patient Adenoma Count at a Large New York City Center Using Population-based Data.
Concurrent Session C2: Communication and Dissemination
- Kathy Mazor: Assessing Patient Perceptions of Communication Throughout Cancer Care: Results of an Initial Administration of a New Item Set.
Concurrent Session C3: Mental Health & Chemical Dependency
- David Carrell: Estimating Prevalence of Clinician-described Opiod Abuse Using Structured Versus Unstructured Clinical Data.
Concurrent Session D4: Topics in Health Services Research, Policy and Costs
- Terry Field: Does Having an Office Visit Within 7 Days After Hospital Discharge Reduce 30-day Readmission?
- Joanna Bulkley: Associations of Gestational Weight Gain with Preterm Birth Among Underweight and Normal Women.
1:15-2:45 CRN Steering Committee, part 2
PCORI Initiative Update
In early 2014, PCORI announced an initiative to fund pragmatic studies to examine several key questions that had been identified by PCORI stakeholders.
Given the scientific advantages of conducting such studies in the CRN setting, the CRN facilitated development and submission of Letters of Intent in response to several of the topics outlined in the PCORI funding announcement. Although at this time we do not know if these LOI submissions will be invited to suibmit a grant application, we are optimistic that at least some of them will. Also, given the limited time for development of the LOI's, the final clinical, patient engagement, and research teams are not yet finalized. Brief summaries are provided below on six LOI's that were submitted. To indicate interest in becoming involved in any of these, please e-mail us.
Management of breast ductal carcinoma in situ (DCIS)
Rinaa Punglia (Dana Farber Cancer Institute)
What are the differences in patient-centered quality of life (pain, fatigue, time to return to baseline functioning) following standard radiation therapy (30 treatments) versus short-course (18 treatments) radiation therapy for ductal carcinoma in situ (DCIS).
Joanne Elmore (University of Washington)
1) Can standardized breast pathology reports with educational summaries improve patients' understanding of their diagnoses and improve clinicians' ability to communicate effectively with their patients?; 2) Can the diagnostic accuracy of pathologists' interpretations of breast tissue specimens be improved by implementing a systemic approach of double reading all biopsies initially interpreted as ductal carcinoma in situ (DCIS) or atypia?
Compare the effectiveness of innovative strategies for enhancing patients' adherence to medication regimens.
Michael Parchman (Group Health Research Institute)
Will patient-centered support for chronic disease medication management during cancer therapy improve patient experiences of care?
Compare the effectiveness of specific features of health insurance on access to care, use of care, and other outcomes that are especially important to patients.
Deb Schrag (Dana Farber Cancer Institute)
Venous thromboembolism and heart failure carry elevated risk after cardiotoxic cancer therapy. Are new oral anticoagulants effective and accepted in this context, in comparison to traditional anticoagulants such as low molecular weight heparin or warfarin?
Strategies for follow-up of pulmonary nodules identified by imaging studies
Michael Gould (KPSC)
With the increasing use of low-dose computed tomography for lung cancer screening in the wake of the results of the National Lung Screening Trial, appropriate screening intervals and follow-up is as yet not clearly defined. We propose a comparison of more versus less intensive radiographic surveillance of patients with small (≤10 mm) pulmonary nodules, to identify differences in clinical and patient-centered outcomes.
Additional Funding Opportunities
Application Deadline: May 20, 2014; September 23, 2014 (LOI due 30 days prior)
National Cancer Institute
- Specialized Programs of Research Excellence (SPOREs) in Human Cancer for Year 2014 (P50). Announcement here.
Application Deadline: June 10, 2014 (LOI due 30 days prior)
National Cancer Institute
- Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control (U01). Announcement here.
Application Deadline: June 20, 2014 (LOI due 30 days prior)
National Cancer Institute
- Research Answers to NCI's Provocative Questions - Group E. R01 announcement here; R21 announcement here.
All times listed are Pacific.[D]
For meeting details, contact Heather Clancy.
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