CRN Monthly Update for April 2014

In this issue:

Message from the Coordinating Center

Pilot Projects Program Update

The CRN invited 27 investigators who submitted Letters of Intent to submit full applications for the CRN Pilot Projects Program. We expect to fund four or five applications.

We will be holding a Q&A style webinar on Monday, April 14, from 12 to 2 pm, PDT, covering information related to the Pilot Project Application Submissions. All investigators, co-investigators, grants administrator and others who may be involved in preparing an Application are invited to attend. We will send a reminder to all investigators invited to submit a Full Pilot Project Application with webinar URL information.

We are gearing up for the big conference next week. Check below for details on where we'll be. See you at HCSRN!

-Larry, Heather & Melissa

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HCSRN Meeting Highlights

3/31 Monday

9am-5pm CRN Scholars Meeting

1-5pm VDW Implementation Group, part 1.

This is the regular working meeting among VDW implementers. Topics tend to be technical and detailed. Those wanting insight in to how the VDW operates at the micro level may wish to attend.

4/1 Tuesday

10-11:15am Poster Session Competition, CRN Scholar Entrants:

11:30-1pm Early Career Investigator Presentations, CRN Scholars

1:15-3:00pm CRN Steering Committee, part 1

3:15-4:45pm Concurrent Session A1: Cancer Methods and Technology

4/2 Wednesday

10-11:15am Poster Session 2: Cancer

2:30-6:30 Dissemination & Implementation Training

Kathy Mazor, Brian Mittman, Russ Glassgow, and Borsika Rabin.

2:30-4:30 VDW Implementation Group (VIG) Meeting, part 2.

Scientists representing research consortia will present on their use of the VDW. The goal is to improve the exchange of information, learnings, and priorities between VDW implementers and VDW users. Mini-Sentinel, Mental Health Research Network, Cancer Research Network, and PORTAL projects will all be presenting. Scientists at all levels and experiences are invited to attend.

4/3 Thursday

10-11:45am

Concurrent Session C1: Colorectal Cancer
Concurrent Session C2: Communication and Dissemination
Concurrent Session C3: Mental Health & Chemical Dependency
Concurrent Session D4: Topics in Health Services Research, Policy and Costs

1:15-2:45 CRN Steering Committee, part 2

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PCORI Initiative Update

In early 2014, PCORI announced an initiative to fund pragmatic studies to examine several key questions that had been identified by PCORI stakeholders.

Given the scientific advantages of conducting such studies in the CRN setting, the CRN facilitated development and submission of Letters of Intent in response to several of the topics outlined in the PCORI funding announcement. Although at this time we do not know if these LOI submissions will be invited to suibmit a grant application, we are optimistic that at least some of them will. Also, given the limited time for development of the LOI's, the final clinical, patient engagement, and research teams are not yet finalized. Brief summaries are provided below on six LOI's that were submitted. To indicate interest in becoming involved in any of these, please e-mail us.

Management of breast ductal carcinoma in situ (DCIS)

Rinaa Punglia (Dana Farber Cancer Institute)

What are the differences in patient-centered quality of life (pain, fatigue, time to return to baseline functioning) following standard radiation therapy (30 treatments) versus short-course (18 treatments) radiation therapy for ductal carcinoma in situ (DCIS).

Joanne Elmore (University of Washington)

1) Can standardized breast pathology reports with educational summaries improve patients' understanding of their diagnoses and improve clinicians' ability to communicate effectively with their patients?; 2) Can the diagnostic accuracy of pathologists' interpretations of breast tissue specimens be improved by implementing a systemic approach of double reading all biopsies initially interpreted as ductal carcinoma in situ (DCIS) or atypia?

Compare the effectiveness of innovative strategies for enhancing patients' adherence to medication regimens.

Michael Parchman (Group Health Research Institute)

Will patient-centered support for chronic disease medication management during cancer therapy improve patient experiences of care?

Compare the effectiveness of specific features of health insurance on access to care, use of care, and other outcomes that are especially important to patients.

Deb Schrag (Dana Farber Cancer Institute)

Venous thromboembolism and heart failure carry elevated risk after cardiotoxic cancer therapy. Are new oral anticoagulants effective and accepted in this context, in comparison to traditional anticoagulants such as low molecular weight heparin or warfarin?

Strategies for follow-up of pulmonary nodules identified by imaging studies

Michael Gould (KPSC)

With the increasing use of low-dose computed tomography for lung cancer screening in the wake of the results of the National Lung Screening Trial, appropriate screening intervals and follow-up is as yet not clearly defined. We propose a comparison of more versus less intensive radiographic surveillance of patients with small (≤10 mm) pulmonary nodules, to identify differences in clinical and patient-centered outcomes.

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Additional Funding Opportunities

Application Deadline: May 20, 2014; September 23, 2014 (LOI due 30 days prior)

National Cancer Institute

Application Deadline: June 10, 2014 (LOI due 30 days prior)

National Cancer Institute

Application Deadline: June 20, 2014 (LOI due 30 days prior)

National Cancer Institute

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CRN Calendar

All times listed are Pacific.

A calendar of upcoming events in April and May [D]

For meeting details, contact Heather Clancy.

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