In this issue:
- Message from the Coordinating Center
- Research Highlights
- Scientific Working Group/Core Updates
- Workshops & Trainings
- Additional Funding Opportunities
- CRN Calendar
Message from the Coordinating Center
Kudos from the Coordinating Center.
There has been a lot of activity around the CRN Pilot and Developmental Program in the last couple of months and we would like to extend our gratitude.
First, we would like to thank the current CRN Pilot and Developmental Project PIs. They presented their work and progress made on their projects thus far in a well-attended webinar on Tuesday, February 25. A wide variety of topics were discussed including end-of-life care among adolescents with cancer and how to use natural language processing to capture cancer-related information. The CRN project portfolio continues to benefit from these projects and we are excited to fund another round of Pilot and Developmental projects in the coming months. We were also very happy to see that some of our Advisory Board members, NCI colleagues, and a number of prospective Pilot Project applicants were able to join the webinar.
Second, a quick thanks to everyone who has been connecting with potential applicants for the next round of Pilot and Developmental Projects. We know that this requires a lot of time and effort, and it is greatly appreciated. You may also be asked to help in the review of the Letter of Intent submissions this month, or the Full Applications that are due May 16 - so thanks in advance.
Upcoming dates to note:
KPNW Site Visit: March 18th-19th
HCSRN Conference: March 31st-April 3rd
-Larry, Heather & Melissa
Each year, the NCI's Epidemiology and Genomics Research Program identifies research highlights based on 10 peer-reviewed manuscripts from EGRP grantees. These research highlights arise from recommendations and voting among EGRP staff, to identify those research findings that have the greatest potential for scientific or public health impact . Three of the ten papers that were selected were based on research grants that are conducted at least in part in CRN Sites. The papers include:
- Diana Miglioretti, et al., The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk, JAMA Pediatrics. 2013 Aug 1;167(8):700-7. This paper grew directly from prior CRN funding, and was previously recognized as the Minnies 2013 Runner-up for Scientific Paper of the Year.
- Candyce Kroenke, et al., High- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis, J Natl Cancer Inst. 2013 May 1;105(9):616-23. Dr. Kroenke is a researcher at the Division of Research, KPNC, and this manuscript is based on Dr. Bette Caan's Life After Cancer Epidemiology (LACE) Study, a cohort of women with breast cancer. LACE Study participants were recruited primarily from KPNC.
- Frank Biro, et al., Onset of breast development in a longitudinal cohort, Pediatrics. 2013 Dec;132(6):1019-27. This manuscript presents key findings related to age at onset of breast development from the three Puberty Studies of the NIEHS/NCI Breast Cancer and the Environment Research Program. The three studies are led by Dr. Biro at Cincinnati Children's Medical Center, Dr. Mary Wolff at Mount Sinai School of Medicine, and the CRN's own Larry Kushi at the DOR.
Scientific Working Group/Core Updates
Communication & Dissemination
The C&D SWG is finalizing plans for the Dissemination and Implementation Science Training Workshop we will host at the 2014 HCSRN Conference. A few spaces are still available. To register, please fill out this survey.
Epidemiology of Prognosis & Outcomes
A multiple-PI NCI application, "Diet and Lifestyle in a Prospective Study of Bladder Cancer Survivors," has been recommended for funding. The contact PI is Marilyn Kwan at KPNC, and the other PIs are Li Tang at the Roswell Park Cancer Institute and Larry Kushi at KPNC. Virginia Quinn is site PI for KPSC. The project aims to enroll approximately 1,800 women and men with bladder cancer to investigate the effects on recurrence of dietary factors, especially cruciferous vegetable intake, including interactions with polymorphisms in isothiocyanate-metabolizing genes and bladder cancer therapies.
Health Care Quality & Cost
The HCQC SWG and the CRN PI's office led a CRN-wide conference call related to proposal opportunities and options related to the PCORI Pragmatic Studies initiative. Specifically, the topic of "Comparing the effectiveness of specific features of health insurance on access to care, use of care, and other outcomes that are especially important to patients."
We have moved CRNnet to PopMedNet V3, which now allows us to start work on the SAS VDW querying capability developed as part of the SPAN project.
Prevention & Screening
The P&S SWG will be holding a webinar on Monday, March 17, 2014, 12 PM PT. Myles Cockburn from the Keck School of Medicine of the University of Southern California will be presenting on issues related to skin cancer screening - Webinar link; Meeting password: crn4pands; Call-in toll-free number: 1-877-668-4490; Access code: 572 215 978.
Seven abstracts related to colorectal cancer screening were submitted by the COLOFIT study team and accepted for presentation at the Digestive Disease Week conference in Chicago, to be held on May 3-6, 2014.
In addition, we had a paper on adenoma detection rate in colorectal cancer screening accepted to the New England Journal of Medicine: Corley DA, et al. Physician adenoma detection rate and colorectal cancer risk and mortality.
The CRN Scholars are preparing draft proposals of various types (R01, 3 and 21 as well as K and ACS). We will hold a mock study section to review these proposals during our semi-annual in-person meeting on March 31 in Phoenix on the day preceding the HCSRN conference. CRN Steering Committee members were invited to participate on the review panel, and review assignments are in process. We expect these reviews to be of great assistance to the Scholars as they move into the next phase of the program and begin submitting applications for funding. Many thanks to the reviewers!
Workshops & Trainings
AACR's Integrative Molecular Epidemiology Workshop
August 11-15, 2014, Boston, MA
Application deadline: Monday, April 14
Applications are now open for the Integrative Molecular Epidemiology Workshop. This five-day workshop is designed to accelerate the training of the next generation of cancer researchers who must be well-skilled in the integration of biology and epidemiology in studies of etiology and outcome. Visit our Web site today to view the full program for this workshop. Space is limited, so apply today! The application deadline is Monday, April 14.
The workshop is primarily targeted toward molecular epidemiologists, but the materials are designed to also be appropriate for geneticists, statisticians, bioinformaticians, molecular biologists, physician scientists, and others who have completed basic course work in epidemiology.
Training Institute for Dissemination and Implementation Research in Health (TIDIRH)
July 21-25, 2014, Harvard University, Boston, MA
Application deadline: April 6, 2014
One of the most critical issues impeding improvements in public health today is the enormous gap between what we know can optimize health and healthcare and what actually gets implemented in every day practice. The science of dissemination and implementation (D&I) seeks to address this gap by understanding how to best ensure that evidence-based strategies to improve health and prevent disease are effectively delivered in clinical and public health practice.
Harvard University, with support from the National Institutes of Health (National Cancer Institute, National Institute of Mental Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Heart, Lung, and Blood Institute, Office of Disease Prevention, and the Office of Behavioral and Social Sciences Research) and the U.S. Department of Veterans Affairs, is sponsoring this 5-day training institute to provide participants with a thorough grounding in conducting dissemination and implementation research in health. Faculty and guest lecturers will consist of leading experts (practitioners and teachers) in theory, implementation and evaluation approaches to D&I, creating partnerships and multi-level, transdisciplinary research teams, research design, methods and analyses appropriate for D&I investigations and conducting research at different and multiple levels of interventions (e.g., clinical, community, policy).
Additional Funding Opportunities
Application Deadline: March 25, 2014 (LOI due 30 days prior)
National Cancer Institute
- Using Social Media to Understand and Address Substance Use and Addiction. R01 Announcement here; R21 announcement here.
- Research Answers to NCI’s Provocative Questions - Group E. R01 announcement here.
Application Deadline: April 1, 2014
American Cancer Society
- Pilot and Exploratory Projects in Palliative Care of Cancer Patients and Their Families. Announcement here.
- The Role of Healthcare and Insurance in Improving Outcomes in Cancer Prevention, Early Detection and Treatment. Announcement here.
Application Deadline: May 20, 2014; September 23, 2014 (LOI due 30 days prior)
National Cancer Institute
- Specialized Programs of Research Excellence (SPOREs) in Human Cancer for Year 2014 (P50). Announcement here.
Application Deadline: June 10, 2014 (LOI due 30 days prior)
National Cancer Institute
- Fundamental Mechanisms of Affective and Decisional Processes in Cancer Control (U01) Announcement here.
Application Deadline: June 20, 2014 (LOI due 30 days prior)
National Cancer Institute
- Research Answers to NCI’s Provocative Questions - Group E. R01 announcement here; R21 announcement here.
All times listed are Pacific.[D]
For detailed meeting information, contact Heather.A.Clancy@kp.org
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