Left ventricular systolic dysfunction after trastuzumab therapy for breast cancer
In addition, novel imaging techniques, such as echocardiographic strain— a measure of the compressibility of cardiac tissue—have been proposed as methods for providing early warning of impending LVSD from trastuzumab. However, studies of strain have examined small samples and were conducted in academic centers with particular expertise in advanced imaging. It is unclear whether echocardiograms performed in community practices would yield comparable strain data.
Accordingly, we propose this pilot project project to demonstrate that 1) electronic medical record data at CRN sites can accurately identify patients with LVSD after trastuzumab, and that 2) existing clinical echocardiograms acquired during routine trastuzumab monitoring can be successfully analyzed for calculation of strain. The results of this pilot will demonstrate feasibility and provide preliminary data for a larger multi-site CRN study using clinical and imaging data to develop a clinically useful risk score for predicting LVSD after trastuzumab. This project fits the interests of the CRN Scientific Working Group on Epidemiology of Prognosis and Outcomes.