This study, led by Dr. Ann Geiger (Wake Forest University; formerly of KPSC), used the prophylactic mastectomy efficacy study cohort of nearly 800 women who had undergone contralateral prophylactic mastectomy, bilateral prophylactic mastectomy, or neither of these surgeries (comparison group) at six CRN sites. A survey ascertained willingness to recommend prophylactic mastectomy, decision satisfaction, breast cancer risk-related stress, body image, and sexual activity. Most women undergoing prophylactic mastectomy were satisfied with their decision and reported quality of life comparable to similarly at-risk women in the comparison group. Investigators also examined decision-making research questions and contributed methods papers pertaining to medical records data validity and the impact of IRB reviews on study operations and response rates.
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