This project, led by Dr. Suzanne Fletcher (HPHC), evaluated the efficacy of bilateral prophylactic mastectomy (BPM) and contralateral prophylactic mastectomy (CPM) among women with unilateral breast cancer in reducing subsequent breast cancer incidence and mortality, compared to women who had not undergone these surgeries. The women who underwent BPM had a significant reduction in breast cancer risk, but approximately two-thirds experienced significant adverse effects. Compared with breast cancer patients without CPM, the risk of contralateral breast cancer in these women was also reduced significantly. The project also evaluated the efficacy of mammography and clinical breast exam in real-world settings and contributed methodologic innovations and analyses.
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