The CYGNET Study: Environmental and Genetic Determinants of Maturation of Girls
CYGNET Study. The CYGNET Study (Cohort Study of Young Girls Nutrition, Environment and Transitions,
U01 ES019435) is an ongoing prospective study that enrolled 444 girls aged 6-8 y at enrollment in 2005-2006.
Study participants have been followed on an annual basis with data collection with self-administered and
interviewer-administered questionnaires; anthropometric and pubertal stage assessments; and collection of
biospecimens including blood, urine and saliva samples. As one of three Puberty Studies in the NIEHS/NCI
Breast Cancer and the Environment Research Program, that are designed to examine associations of
environmental and other factors on pubertal maturation, we have created an outstanding resource to
investigate a variety of factors in age-at-onset of breast development and other hallmarks of maturation.
In order to ensure that the data and biospecimens that have been collected in this study are available to
study and consortium investigators as well as to the broader scientific community, we plan to document
databases and biospecimen resources in standardized fashion across the Puberty Studies consortium, and to
finalize processes to guide access to and use of these resources. We also propose to maintain contact with
study participants and their families by creating an updated individualized report for study participants that
provides them with their biomarker results. Finally, we plan to continue our scientific productivity by supporting
data analyses and publication of manuscripts. These activities will ensure that the CYGNET Study resources
will continue to be available for the scientific community to contribute to knowledge about factors that influence
the transition of girls through adolescence into young adulthood.