Use of multiple biomarkers with the risk of ovarian cancer algorithm (ROCA) for early detection of ovarian cancer in female carriers of BRCA 1 and BRCA 2 mutations.

The objectives of this study will be to: 1) To test the feasibility of ROCA surveillance for ovarian cancer screening of women with BRCA mutations using two biomarkers, CA 125 and HE4. 2) To obtain preliminary estimates of test performance (specificity, positive predictive value (PPV)) of ROCA to determine if the specificity is maintained compared to the standard threshold cut-off. 3) Evaluate patient compliance and test acceptability with ROCA biomarker surveillance and compare with compliance and acceptability with standard ultrasound and CA 125 surveillance. 4) Collect longitudinal blood specimens for novel biomarker assessment, validation and algorithm development in this select population in collaboration with Dr. Skates at MGH

<< Back to the list of CRN projects

Loading…