Whole Genome Sequencing in Contralateral Breast Cancer

This study explores Whole Genome Sequencing (WGS) in a population of invasive, contralateral breast cancer cases that we have been studying in a contract from NCI. The parent project studies a range of molecular and treatment factors that may predispose to the development of a second (contralateral) breast cancer. The study seeks to examine WGS in a subgroup of the breast cancer population, n=124, who developed a second, contralateral invasive breast cancer treated with a mastectomy and an axillary node dissection. The specific materials requested are uninvolved, negative axillary nodes from which the NCI investigators will extract cores of normal tissue for sequencing. Of the 124 cases, 83 had no spread of the cancer to axillary nodes. We sent deidentified pathology reports to NCI who examined these pathology reports and identified, where specifically indicated, the particular nodal specimens of interest--n=26. The remaining c

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