Clinical & Pathologic Predictors of Ductal Carcinoma in Situ

In this project, led by Dr. Laurel Habel (KPNC), investigators at three CRN sites are studying clinical and pathologic factors that could be used to identify DCIS patients at high and low recurrence risk. From medical records, investigators have identified DCIS patients treated with breast-conserving surgery (BCS) and followed for recurrence. Recurrence rates after BCS for DCIS have declined as treatment with adjuvant radiotherapy and tamoxifen have increased; adjuvant treatment use does not appear to differ markedly across racial/ethnic groups; and surveillance mammography after BCS for DCIS declines over time and becomes inadequate. This large, comprehensive study on prognostic factors will improve understanding of the natural history of DCIS and help in developing individually tailored DCIS treatment strategies. It also serves as a model of a CRN project that benefits from the unique electronic and biologic specimens available in the CRN health plans.

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